TY - GEN AU - SanGiovanni,John Paul AU - Chen,Jing AU - Sapieha,Przemyslaw AU - Aderman,Christopher M AU - Stahl,Andreas AU - Clemons,Traci E AU - Chew,Emily Y AU - Smith,Lois E H TI - DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ω-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways SN - 1932-6203 PY - 2013///0627 KW - Aged KW - Aged, 80 and over KW - Animals KW - Cohort Studies KW - Complement System Proteins KW - genetics KW - Fatty Acids, Omega-3 KW - metabolism KW - Female KW - Gene Expression Profiling KW - Gene Regulatory Networks KW - Heat-Shock Proteins KW - chemistry KW - Humans KW - Macular Degeneration KW - Male KW - Mice KW - Neovascularization, Pathologic KW - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha KW - Polymorphism, Single Nucleotide KW - Retina KW - Signal Transduction KW - Transcription Factors KW - Vascular Endothelial Growth Factor A N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1371/journal.pone.0053155 ER -