TY - GEN AU - Gong,Bing AU - Pan,Yong AU - Vempati,Prashant AU - Zhao,Wei AU - Knable,Lindsay AU - Ho,Lap AU - Wang,Jun AU - Sastre,Magdalena AU - Ono,Kenjiro AU - Sauve,Anthony A AU - Pasinetti,Giulio M TI - Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models SN - 1558-1497 PY - 2013///1211 KW - Alzheimer Disease KW - drug therapy KW - Amyloid Precursor Protein Secretases KW - antagonists & inhibitors KW - Animals KW - Aspartic Acid Endopeptidases KW - Cells, Cultured KW - Cognition Disorders KW - Disease Models, Animal KW - Gene Expression Regulation KW - Mice KW - Mice, Inbred C57BL KW - Mice, Transgenic KW - Mitochondria KW - drug effects KW - Niacinamide KW - analogs & derivatives KW - Organ Culture Techniques KW - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha KW - Pyridinium Compounds KW - Transcription Factors KW - biosynthesis KW - Up-Regulation N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S UR - https://doi.org/10.1016/j.neurobiolaging.2012.12.005 ER -