TY - GEN AU - Song,H AU - Boo,J Hyun AU - Kim,K Ho AU - Kim,C AU - Kim,Y-E AU - Ahn,J-H AU - Jeon,G Sun AU - Ryu,H AU - Kang,D E AU - Mook-Jung,I TI - Critical role of presenilin-dependent γ-secretase activity in DNA damage-induced promyelocytic leukemia protein expression and apoptosis SN - 1476-5403 PY - 2013///0911 KW - Alzheimer Disease KW - metabolism KW - Amyloid Precursor Protein Secretases KW - antagonists & inhibitors KW - Animals KW - Apoptosis KW - drug effects KW - Brain KW - Camptothecin KW - toxicity KW - Carbamates KW - pharmacology KW - Cell Line KW - DNA Damage KW - Dipeptides KW - Gene Expression KW - Gene Knockout Techniques KW - HEK293 Cells KW - Humans KW - Leukemia, Promyelocytic, Acute KW - Mice KW - Nuclear Proteins KW - Presenilins KW - deficiency KW - Promyelocytic Leukemia Protein KW - RNA Interference KW - RNA, Messenger KW - RNA, Small Interfering KW - Signal Transduction KW - Transcription Factors KW - Tumor Suppressor Protein p53 KW - Tumor Suppressor Proteins KW - Up-Regulation N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/cdd.2012.162 ER -