Critical role of presenilin-dependent γ-secretase activity in DNA damage-induced promyelocytic leukemia protein expression and apoptosis. [electronic resource]
- Cell death and differentiation Apr 2013
- 639-48 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5403
10.1038/cdd.2012.162 doi
Alzheimer Disease--metabolism Amyloid Precursor Protein Secretases--antagonists & inhibitors Animals Apoptosis--drug effects Brain--metabolism Camptothecin--toxicity Carbamates--pharmacology Cell Line DNA Damage--drug effects Dipeptides--pharmacology Gene Expression--drug effects Gene Knockout Techniques HEK293 Cells Humans Leukemia, Promyelocytic, Acute--metabolism Mice Nuclear Proteins--antagonists & inhibitors Presenilins--deficiency Promyelocytic Leukemia Protein RNA Interference RNA, Messenger--metabolism RNA, Small Interfering--metabolism Signal Transduction Transcription Factors--antagonists & inhibitors Tumor Suppressor Protein p53--metabolism Tumor Suppressor Proteins--antagonists & inhibitors Up-Regulation