TY  - GEN
AU  - Zamek-Gliszczynski,Maciej J
AU  - Abraham,Trent L
AU  - Alberts,Jeffrey J
AU  - Kulanthaivel,Palaniappan
AU  - Jackson,Kimberley A
AU  - Chow,Kay H
AU  - McCann,Denis J
AU  - Hu,Haitao
AU  - Anderson,Shelby
AU  - Furr,Nathan A
AU  - Barbuch,Robert J
AU  - Cassidy,Kenneth C
TI  - Pharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure
SN  - 1521-009X
PY  - 2013///1104
KW  - Animals
KW  - Antineoplastic Agents
KW  - metabolism
KW  - Bile
KW  - Dogs
KW  - Feces
KW  - chemistry
KW  - Glycogen Synthase Kinase 3
KW  - antagonists & inhibitors
KW  - Glycogen Synthase Kinase 3 beta
KW  - Heterocyclic Compounds, 3-Ring
KW  - pharmacokinetics
KW  - Humans
KW  - Male
KW  - Maleimides
KW  - Microsomes, Liver
KW  - Protein Kinase Inhibitors
KW  - Rats
KW  - Urine
N1  - Publication Type: Clinical Trial, Phase I; Comparative Study; Journal Article; Multicenter Study
UR  - https://doi.org/10.1124/dmd.112.048488
ER  -