Zamek-Gliszczynski, Maciej J <br/><br/>
Pharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  Apr 2013 
 - 714-26 p.  digital 
<br/><br/> Publication Type: Clinical Trial, Phase I; Comparative Study; Journal Article; Multicenter Study 
<br/><br/><label>ISSN: </label>1521-009X 
<br/><br/><label>Standard No.: </label>10.1124/dmd.112.048488  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--metabolism<br/>Bile--metabolism<br/>Dogs<br/>Feces--chemistry<br/>Glycogen Synthase Kinase 3--antagonists & inhibitors<br/>Glycogen Synthase Kinase 3 beta<br/>Heterocyclic Compounds, 3-Ring--pharmacokinetics<br/>Humans<br/>Male<br/>Maleimides--pharmacokinetics<br/>Microsomes, Liver--metabolism<br/>Protein Kinase Inhibitors--metabolism<br/>Rats<br/>Urine--chemistry