Liang, Yingjian

Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma. [electronic resource] - Hepatology (Baltimore, Md.) May 2013 - 1847-57 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1527-3350

10.1002/hep.26224 doi


Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Benzylidene Compounds--pharmacology
Carcinoma, Hepatocellular--drug therapy
Cell Line, Tumor
Cell Movement--drug effects
Cell Survival--drug effects
Drug Resistance, Neoplasm--drug effects
Drug Therapy, Combination
Humans
Hypoxia--physiopathology
Hypoxia-Inducible Factor 1, alpha Subunit--antagonists & inhibitors
Liver Neoplasms--drug therapy
Male
Mice
Mice, Inbred BALB C
Mice, Nude
NF-kappa B--metabolism
Niacinamide--analogs & derivatives
Phenylurea Compounds--pharmacology
Piperidones--pharmacology
Sorafenib
Treatment Outcome
Von Hippel-Lindau Tumor Suppressor Protein--metabolism
Xenograft Model Antitumor Assays