TY  - GEN
AU  - Chung,Suyoun
AU  - Suzuki,Hanae
AU  - Miyamoto,Takashi
AU  - Takamatsu,Naofumi
AU  - Tatsuguchi,Ayako
AU  - Ueda,Koji
AU  - Kijima,Kyoko
AU  - Nakamura,Yusuke
AU  - Matsuo,Yo
TI  - Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer
SN  - 1949-2553
PY  - 2013///0812
KW  - Administration, Oral
KW  - Animals
KW  - Antineoplastic Agents
KW  - administration & dosage
KW  - Cell Proliferation
KW  - drug effects
KW  - Dose-Response Relationship, Drug
KW  - Drug Design
KW  - Female
KW  - High-Throughput Screening Assays
KW  - Humans
KW  - Inhibitory Concentration 50
KW  - Injections, Intravenous
KW  - MCF-7 Cells
KW  - Male
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Mice, Inbred NOD
KW  - Mice, SCID
KW  - Microfilament Proteins
KW  - metabolism
KW  - Molecular Structure
KW  - Molecular Targeted Therapy
KW  - NIH 3T3 Cells
KW  - Naphthyridines
KW  - Neoplasms
KW  - drug therapy
KW  - Phosphorylation
KW  - Proteasome Endopeptidase Complex
KW  - Protein Kinase Inhibitors
KW  - Protein Serine-Threonine Kinases
KW  - antagonists & inhibitors
KW  - RNA Interference
KW  - Small Molecule Libraries
KW  - Structure-Activity Relationship
KW  - Time Factors
KW  - Transfection
KW  - Tumor Burden
KW  - Xenograft Model Antitumor Assays
KW  - src Homology Domains
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.18632/oncotarget.790
ER  -