Combination of a selective activator of the glucocorticoid receptor Compound A with a proteasome inhibitor as a novel strategy for chemotherapy of hematologic malignancies. [electronic resource]
- Cell cycle (Georgetown, Tex.) Jan 2013
- 133-44 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1551-4005
10.4161/cc.23048 doi
Apoptosis--drug effects Boronic Acids--therapeutic use Bortezomib Cell Line, Tumor Dexamethasone--toxicity Dimerization Drug Synergism Hematologic Neoplasms--drug therapy Humans K562 Cells Lymphoma--drug therapy NF-kappa B--antagonists & inhibitors Precursor T-Cell Lymphoblastic Leukemia-Lymphoma--drug therapy Proteasome Inhibitors--therapeutic use Pyrazines--therapeutic use RNA Interference RNA, Small Interfering--metabolism Receptors, Glucocorticoid--agonists Transcription Factor AP-1--antagonists & inhibitors Transcriptional Activation Triazoles--therapeutic use Tumor Cells, Cultured