Moore, Samantha F

Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets. [electronic resource] - The Journal of biological chemistry Feb 2013 - 3918-28 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M112.429936 doi


Amino Acid Substitution
Animals
Blood Platelets--metabolism
Fibrinogen--metabolism
Glycogen Synthase Kinase 3--antagonists & inhibitors
Glycogen Synthase Kinase 3 beta
Heterocyclic Compounds, 3-Ring--pharmacology
Mice
Mice, Knockout
Mutation, Missense
P-Selectin--biosynthesis
Phosphorylation--drug effects
Platelet Aggregation--drug effects
Platelet Glycoprotein GPIIb-IIIa Complex--genetics
Protein Kinase C-alpha--genetics
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
Pyridines--pharmacology
Pyrimidines--pharmacology
Secretory Vesicles--genetics
Thrombin--metabolism