Jessen, Walter J

MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. [electronic resource] - The Journal of clinical investigation Jan 2013 - 340-7 p. digital

Publication Type: Clinical Trial; Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

1558-8238

10.1172/JCI60578 doi


Animals
Benzamides--pharmacology
Child
Child, Preschool
Diphenylamine--analogs & derivatives
Extracellular Signal-Regulated MAP Kinases--genetics
Female
Humans
Male
Mice
Mice, Mutant Strains
Mitogen-Activated Protein Kinase Kinases--antagonists & inhibitors
Neoplasm Transplantation
Neurofibromatosis 1--drug therapy
Oncogene Protein p21(ras)--genetics
Peripheral Nervous System Neoplasms--drug therapy
Transcriptome--drug effects
Transplantation, Heterologous
Xenograft Model Antitumor Assays
raf Kinases--genetics