MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. [electronic resource]
- The Journal of clinical investigation Jan 2013
- 340-7 p. digital
Publication Type: Clinical Trial; Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1558-8238
10.1172/JCI60578 doi
Animals Benzamides--pharmacology Child Child, Preschool Diphenylamine--analogs & derivatives Extracellular Signal-Regulated MAP Kinases--genetics Female Humans Male Mice Mice, Mutant Strains Mitogen-Activated Protein Kinase Kinases--antagonists & inhibitors Neoplasm Transplantation Neurofibromatosis 1--drug therapy Oncogene Protein p21(ras)--genetics Peripheral Nervous System Neoplasms--drug therapy Transcriptome--drug effects Transplantation, Heterologous Xenograft Model Antitumor Assays raf Kinases--genetics