Therapeutic effect of MG-132 on diabetic cardiomyopathy is associated with its suppression of proteasomal activities: roles of Nrf2 and NF-κB. [electronic resource]
- American journal of physiology. Heart and circulatory physiology Feb 2013
- H567-78 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1522-1539
10.1152/ajpheart.00650.2012 doi
Animals Antioxidants--metabolism Cysteine Proteinase Inhibitors--therapeutic use Diabetes Mellitus, Experimental--complications Diabetes Mellitus, Type 1--complications Diabetic Cardiomyopathies--diagnostic imaging Disease Models, Animal Female Gene Expression Regulation--drug effects Hypertrophy, Left Ventricular--drug therapy Leupeptins--therapeutic use Mice Mice, Transgenic Myocarditis--drug therapy NF-E2-Related Factor 2--physiology NF-kappa B--physiology Oxidative Stress--drug effects Proteasome Inhibitors--therapeutic use Ultrasonography