Protective mechanisms of simvastatin in experimental periodontal disease. [electronic resource]
- Journal of periodontology Aug 2013
- 1145-57 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1943-3670
10.1902/jop.2012.120114 doi
Alanine Transaminase--drug effects Alkaline Phosphatase--drug effects Alveolar Bone Loss--prevention & control Animals Anti-Inflammatory Agents--therapeutic use Antioxidants--therapeutic use Aspartate Aminotransferases--drug effects Bone Morphogenetic Protein 2--drug effects Female Gingiva--drug effects Glutathione--drug effects Hydroxymethylglutaryl-CoA Reductase Inhibitors--therapeutic use Interleukin-10--analysis Interleukin-1beta--drug effects Malondialdehyde--analysis Matrix Metalloproteinase 1--drug effects Matrix Metalloproteinase 8--drug effects Nitrates--analysis Nitric Oxide Synthase Type II--drug effects Nitrites--analysis Osteoprotegerin--drug effects Oxidative Stress--drug effects Periodontitis--prevention & control Peroxidase--drug effects RANK Ligand--drug effects Rats Rats, Wistar Receptor Activator of Nuclear Factor-kappa B--drug effects Simvastatin--therapeutic use Tumor Necrosis Factor-alpha--drug effects