TY - GEN AU - Hsieh,Yi-Hsuan AU - Su,Ih-Jen AU - Yen,Chia-Jui AU - Tsai,Ting-Fen AU - Tsai,Hung-Wen AU - Tsai,Han-Ni AU - Huang,Yu-Jun AU - Chen,Yen-Yu AU - Ai,Yu-Lin AU - Kao,Lin-Yuan AU - Hsieh,Wen-Chuan AU - Wu,Han-Chieh AU - Huang,Wenya TI - Histone deacetylase inhibitor suberoylanilide hydroxamic acid suppresses the pro-oncogenic effects induced by hepatitis B virus pre-S2 mutant oncoprotein and represents a potential chemopreventive agent in high-risk chronic HBV patients SN - 1460-2180 PY - 2013///0403 KW - Animals KW - Apoptosis KW - drug effects KW - Blotting, Western KW - COP9 Signalosome Complex KW - Carcinoma, Hepatocellular KW - etiology KW - Cell Cycle KW - Cell Nucleus KW - Cell Proliferation KW - Cyclin-Dependent Kinase Inhibitor p27 KW - genetics KW - Cytoplasm KW - Female KW - Fluorescent Antibody Technique KW - Hepatitis B Surface Antigens KW - Hepatitis B virus KW - Hepatitis B, Chronic KW - complications KW - Hepatocytes KW - cytology KW - Histone Deacetylase Inhibitors KW - pharmacology KW - Humans KW - Hydroxamic Acids KW - Immunoenzyme Techniques KW - Immunoprecipitation KW - Intracellular Signaling Peptides and Proteins KW - Liver Neoplasms KW - Male KW - Mice KW - Mice, Inbred C57BL KW - Mice, Transgenic KW - Mutant Proteins KW - Mutation KW - Nuclear Proteins KW - Peptide Hydrolases KW - Protein Precursors KW - RNA, Messenger KW - Real-Time Polymerase Chain Reaction KW - Reverse Transcriptase Polymerase Chain Reaction KW - TATA Box Binding Protein-Like Proteins KW - Two-Hybrid System Techniques KW - Vorinostat N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1093/carcin/bgs365 ER -