TY  - GEN
AU  - Anthoney,D Alan
AU  - Naik,Jay
AU  - Macpherson,Iain R J
AU  - Crawford,Donna
AU  - Hartley,John M
AU  - Hartley,Janet A
AU  - Saito,Tomohisa
AU  - Abe,Masaichi
AU  - Jones,Keith
AU  - Miwa,Masanori
AU  - Twelves,Christopher
AU  - Evans,T R J
TI  - Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses
SN  - 1471-2407
PY  - 2013///0523
KW  - Adult
KW  - Aged
KW  - Aldehyde Oxidase
KW  - genetics
KW  - Area Under Curve
KW  - Cytochrome P-450 CYP2D6
KW  - DNA Damage
KW  - Dipeptides
KW  - adverse effects
KW  - Dose-Response Relationship, Drug
KW  - Female
KW  - Glucuronosyltransferase
KW  - Heterocyclic Compounds, 4 or More Rings
KW  - Humans
KW  - Infusions, Intravenous
KW  - Male
KW  - Metabolic Clearance Rate
KW  - Middle Aged
KW  - Molecular Structure
KW  - Neoplasms
KW  - drug therapy
KW  - Pharmacogenetics
KW  - methods
KW  - Polymorphism, Genetic
KW  - Prodrugs
KW  - Thrombocytopenia
KW  - chemically induced
KW  - Topoisomerase I Inhibitors
KW  - Treatment Outcome
N1  - Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1186/1471-2407-12-536
ER  -