Effect of dicycloplatin, a novel platinum chemotherapeutical drug, on inhibiting cell growth and inducing cell apoptosis. [electronic resource]
- PloS one 2012
- e48994 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0048994 doi
Antineoplastic Agents--chemistry Apoptosis--drug effects Caspase 3--metabolism Caspase 8--metabolism Cell Line, Tumor Cell Proliferation--drug effects Drug Combinations Gene Expression Regulation, Neoplastic Glutamates--pharmacology Hep G2 Cells Humans Membrane Potential, Mitochondrial--drug effects Models, Biological Organoplatinum Compounds--pharmacology Platinum--chemistry Poly(ADP-ribose) Polymerases--metabolism Reactive Oxygen Species--metabolism Receptors, Death Domain--metabolism Signal Transduction--drug effects Tumor Suppressor Protein p53--genetics