Seitz, Christian <br/><br/>
The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talk.  [electronic resource] 

 -  International journal of cancer  Jun 2013 
 - 2682-93 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1097-0215 
<br/><br/><label>Standard No.: </label>10.1002/ijc.27935  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antimalarials--pharmacology<br/>Apoptosis--drug effects<br/>Autophagy<br/>Blotting, Western<br/>Cell Membrane Permeability--drug effects<br/>Chloroquine--pharmacology<br/>Drug Synergism<br/>Enzyme Inhibitors--pharmacology<br/>Humans<br/>Imidazoles--pharmacology<br/>Immunoprecipitation<br/>Lysosomes--drug effects<br/>Membrane Potential, Mitochondrial--drug effects<br/>Mitochondria--drug effects<br/>Neuroblastoma--drug therapy<br/>Phosphatidylinositol 3-Kinases--metabolism<br/>Phosphoinositide-3 Kinase Inhibitors<br/>Proto-Oncogene Proteins c-akt--metabolism<br/>Quinolines--pharmacology<br/>Reactive Oxygen Species--metabolism<br/>Signal Transduction--drug effects<br/>TOR Serine-Threonine Kinases--antagonists & inhibitors<br/>Tumor Cells, Cultured<br/>bcl-2-Associated X Protein--metabolism