TY - GEN AU - Westra,Edze R AU - Swarts,Daan C AU - Staals,Raymond H J AU - Jore,Matthijs M AU - Brouns,Stan J J AU - van der Oost,John TI - The CRISPRs, they are a-changin': how prokaryotes generate adaptive immunity SN - 1545-2948 PY - 2013///0422 KW - Amino Acid Motifs KW - Bacteriophages KW - genetics KW - CRISPR-Associated Proteins KW - DNA Helicases KW - DNA, Viral KW - Deoxyribonucleases, Type I Site-Specific KW - Endodeoxyribonucleases KW - Escherichia coli K12 KW - Escherichia coli Proteins KW - Gene Expression Regulation, Bacterial KW - Genes, Bacterial KW - Lysogeny KW - Prophages KW - Species Specificity KW - Virus Internalization N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review UR - https://doi.org/10.1146/annurev-genet-110711-155447 ER -