TY  - GEN
AU  - Kudo,Toshiyuki
AU  - Hisaka,Akihiro
AU  - Sugiyama,Yuichi
AU  - Ito,Kiyomi
TI  - Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes
SN  - 1521-009X
PY  - 2013///0712
KW  - Area Under Curve
KW  - Aryl Hydrocarbon Hydroxylases
KW  - antagonists & inhibitors
KW  - Biotransformation
KW  - Carbamates
KW  - blood
KW  - Computer Simulation
KW  - Cytochrome P-450 CYP2C8
KW  - Cytochrome P-450 CYP3A
KW  - metabolism
KW  - Cytochrome P-450 CYP3A Inhibitors
KW  - Drug Interactions
KW  - Enzyme Inhibitors
KW  - Gemfibrozil
KW  - Glucuronides
KW  - pharmacology
KW  - Humans
KW  - Hypoglycemic Agents
KW  - Itraconazole
KW  - Least-Squares Analysis
KW  - Liver
KW  - drug effects
KW  - Liver-Specific Organic Anion Transporter 1
KW  - Models, Biological
KW  - Nonlinear Dynamics
KW  - Organic Anion Transporters
KW  - Piperidines
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1124/dmd.112.049460
ER  -