Forsyth, Timothy <br/><br/>
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors.  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  Dec 2012 
 - 7653-8 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1464-3405 
<br/><br/><label>Standard No.: </label>10.1016/j.bmcl.2012.10.007  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--administration & dosage<br/>Apoptosis--drug effects<br/>Cell Proliferation--drug effects<br/>Crystallography, X-Ray<br/>Dogs<br/>Dose-Response Relationship, Drug<br/>Haplorhini<br/>High-Throughput Screening Assays<br/>Janus Kinase 2--antagonists & inhibitors<br/>Mice<br/>Mice, Nude<br/>Models, Molecular<br/>Molecular Structure<br/>Neoplasms, Experimental--drug therapy<br/>Proline--administration & dosage<br/>Protein Kinase Inhibitors--administration & dosage<br/>Pyrimidines--administration & dosage<br/>Rats<br/>Structure-Activity Relationship<br/>Xenograft Model Antitumor Assays