TY  - GEN
AU  - Wilhelm,Adriana
AU  - Lopez-Garcia,Laura A
AU  - Busschots,Katrien
AU  - Fröhner,Wolfgang
AU  - Maurer,Frauke
AU  - Boettcher,Stefan
AU  - Zhang,Hua
AU  - Schulze,Jörg O
AU  - Biondi,Ricardo M
AU  - Engel,Matthias
TI  - 2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept
SN  - 1520-4804
PY  - 2013///0205
KW  - Allosteric Site
KW  - Binding Sites
KW  - DNA Helicases
KW  - antagonists & inhibitors
KW  - Drug Design
KW  - Enzyme Activation
KW  - Humans
KW  - Immunoblotting
KW  - Malonates
KW  - chemical synthesis
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Muscle Cells
KW  - drug effects
KW  - Prodrugs
KW  - Protein Binding
KW  - Protein Kinase Inhibitors
KW  - Protein Serine-Threonine Kinases
KW  - Pyruvate Dehydrogenase Acetyl-Transferring Kinase
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/jm3010477
ER  -