Wilhelm, Adriana <br/><br/>
2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept.  [electronic resource] 

 -  Journal of medicinal chemistry  Nov 2012 
 - 9817-30 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm3010477  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Allosteric Site<br/>Binding Sites<br/>DNA Helicases--antagonists & inhibitors<br/>Drug Design<br/>Enzyme Activation<br/>Humans<br/>Immunoblotting<br/>Malonates--chemical synthesis<br/>Models, Molecular<br/>Molecular Structure<br/>Muscle Cells--drug effects<br/>Prodrugs--chemical synthesis<br/>Protein Binding<br/>Protein Kinase Inhibitors--chemical synthesis<br/>Protein Serine-Threonine Kinases--antagonists & inhibitors<br/>Pyruvate Dehydrogenase Acetyl-Transferring Kinase<br/>Structure-Activity Relationship