Hickey, Christopher J

Lenalidomide-mediated enhanced translation of C/EBPα-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia. [electronic resource] - Blood Jan 2013 - 159-69 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

1528-0020

10.1182/blood-2012-05-428573 doi


Adult
Animals
Antimetabolites, Antineoplastic--pharmacology
CCAAT-Enhancer-Binding Proteins--biosynthesis
Cell Line, Tumor--drug effects
Cytarabine--pharmacology
Frameshift Mutation
Gene Expression Regulation, Leukemic--drug effects
Humans
Immunologic Factors--pharmacology
K562 Cells
Lenalidomide
Leukemia, Myeloid, Acute--drug therapy
Mice
Mice, Inbred NOD
Mice, SCID
MicroRNAs--biosynthesis
Neoplasm Proteins--biosynthesis
Point Mutation
Promoter Regions, Genetic--genetics
Protein Isoforms--biosynthesis
Protein Structure, Tertiary
RNA, Neoplasm--biosynthesis
Recombinant Fusion Proteins--physiology
Thalidomide--analogs & derivatives
Up-Regulation--drug effects
Xenograft Model Antitumor Assays