Li, Guo-fu <br/><br/>
Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole-body physiologically based pharmacokinetic modeling.  [electronic resource] 

 -  Acta pharmacologica Sinica  Nov 2012 
 - 1359-71 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1745-7254 
<br/><br/><label>Standard No.: </label>10.1038/aps.2012.103  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Intravenous<br/>Administration, Oral<br/>Adrenergic beta-1 Receptor Antagonists--administration & dosage<br/>Adult<br/>Area Under Curve<br/>Bisoprolol--administration & dosage<br/>Computer Simulation<br/>Dose-Response Relationship, Drug<br/>Female<br/>Humans<br/>Male<br/>Middle Aged<br/>Models, Biological<br/>Monte Carlo Method<br/>Renal Insufficiency--physiopathology<br/>Tissue Distribution<br/>Young Adult