Tsubaki, Masanobu <br/><br/>
Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway.  [electronic resource] 

 -  Biochemical pharmacology  Jan 2013 
 - 163-72 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1873-2968 
<br/><br/><label>Standard No.: </label>10.1016/j.bcp.2012.10.009  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Alendronate--adverse effects<br/>Antineoplastic Agents--adverse effects<br/>Apoptosis--drug effects<br/>Apoptosis Regulatory Proteins--antagonists & inhibitors<br/>Bcl-2-Like Protein 11<br/>Bone Density Conservation Agents--adverse effects<br/>Cell Line, Tumor<br/>Cell Nucleus--drug effects<br/>Cell Survival--drug effects<br/>Diphosphonates--adverse effects<br/>Gene Expression Regulation, Neoplastic--drug effects<br/>Gene Silencing<br/>Hematologic Neoplasms--drug therapy<br/>Humans<br/>Imidazoles--adverse effects<br/>MAP Kinase Signaling System--drug effects<br/>Membrane Proteins--antagonists & inhibitors<br/>Neoplasm Proteins--antagonists & inhibitors<br/>Protein Kinase Inhibitors--pharmacology<br/>Protein Prenylation--drug effects<br/>Proto-Oncogene Proteins--antagonists & inhibitors<br/>Proto-Oncogene Proteins p21(ras)--antagonists & inhibitors<br/>Signal Transduction--drug effects<br/>TOR Serine-Threonine Kinases--antagonists & inhibitors