TY  - GEN
AU  - Gerritz,Samuel W
AU  - Zhai,Weixu
AU  - Shi,Shuhao
AU  - Zhu,Shirong
AU  - Toyn,Jeremy H
AU  - Meredith,Jere E
AU  - Iben,Lawrence G
AU  - Burton,Catherine R
AU  - Albright,Charles F
AU  - Good,Andrew C
AU  - Tebben,Andrew J
AU  - Muckelbauer,Jodi K
AU  - Camac,Daniel M
AU  - Metzler,William
AU  - Cook,Lynda S
AU  - Padmanabha,Ramesh
AU  - Lentz,Kimberley A
AU  - Sofia,Michael J
AU  - Poss,Michael A
AU  - Macor,John E
AU  - Thompson,Lorin A
TI  - Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis
SN  - 1520-4804
PY  - 2013///0226
KW  - Amyloid Precursor Protein Secretases
KW  - antagonists & inhibitors
KW  - Amyloid beta-Peptides
KW  - metabolism
KW  - Amyloid beta-Protein Precursor
KW  - genetics
KW  - Animals
KW  - Aspartic Acid Endopeptidases
KW  - Brain
KW  - Cell Line
KW  - Crystallography, X-Ray
KW  - Guanidines
KW  - chemical synthesis
KW  - Humans
KW  - Isoxazoles
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Mutation
KW  - Peptide Fragments
KW  - Protein Binding
KW  - Radioligand Assay
KW  - Rats
KW  - Small Molecule Libraries
KW  - Solid-Phase Synthesis Techniques
KW  - Solutions
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm300931y
ER  -