Gerritz, Samuel W <br/><br/>
Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis.  [electronic resource] 

 -  Journal of medicinal chemistry  Nov 2012 
 - 9208-23 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm300931y  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amyloid Precursor Protein Secretases--antagonists & inhibitors<br/>Amyloid beta-Peptides--metabolism<br/>Amyloid beta-Protein Precursor--genetics<br/>Animals<br/>Aspartic Acid Endopeptidases--antagonists & inhibitors<br/>Brain--metabolism<br/>Cell Line<br/>Crystallography, X-Ray<br/>Guanidines--chemical synthesis<br/>Humans<br/>Isoxazoles--chemical synthesis<br/>Models, Molecular<br/>Molecular Structure<br/>Mutation<br/>Peptide Fragments--metabolism<br/>Protein Binding<br/>Radioligand Assay<br/>Rats<br/>Small Molecule Libraries<br/>Solid-Phase Synthesis Techniques<br/>Solutions<br/>Structure-Activity Relationship