TY  - GEN
AU  - van der Vries,Erhard
AU  - Collins,Patrick J
AU  - Vachieri,Sebastien G
AU  - Xiong,Xiaoli
AU  - Liu,Junfeng
AU  - Walker,Philip A
AU  - Haire,Lesley F
AU  - Hay,Alan J
AU  - Schutten,Martin
AU  - Osterhaus,Albert D M E
AU  - Martin,Steve R
AU  - Boucher,Charles A B
AU  - Skehel,John J
AU  - Gamblin,Steve J
TI  - H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis
SN  - 1553-7374
PY  - 2013///0509
KW  - Adamantane
KW  - pharmacology
KW  - Amino Acid Substitution
KW  - Antiviral Agents
KW  - Binding Sites
KW  - genetics
KW  - Crystallography, X-Ray
KW  - Drug Resistance, Viral
KW  - Enzyme Inhibitors
KW  - Humans
KW  - Hydrophobic and Hydrophilic Interactions
KW  - Influenza A Virus, H1N1 Subtype
KW  - drug effects
KW  - Influenza, Human
KW  - drug therapy
KW  - Mutation
KW  - Neuraminidase
KW  - antagonists & inhibitors
KW  - Oseltamivir
KW  - Pandemics
KW  - Protein Conformation
KW  - Zanamivir
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1371/journal.ppat.1002914
ER  -