Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology. [electronic resource]
- Journal of medicinal chemistry Nov 2012
- 8997-9008 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
1520-4804
10.1021/jm3008618 doi
Alzheimer Disease--drug therapy Animals Apolipoprotein E4--chemistry Brain Injuries--metabolism Endoplasmic Reticulum--metabolism Golgi Apparatus--metabolism Humans Lipid Metabolism Models, Molecular Molecular Targeted Therapy Neurons--metabolism Protein Conformation Protein Folding--drug effects Protein Transport Proteostasis Deficiencies--drug therapy Structure-Activity Relationship