TY - GEN AU - Sidique,Shyama AU - Dhanya,Raveendra-Panickar AU - Sheffler,Douglas J AU - Nickols,Hilary Highfield AU - Yang,Li AU - Dahl,Russell AU - Mangravita-Novo,Arianna AU - Smith,Layton H AU - D'Souza,Manoranjan S AU - Semenova,Svetlana AU - Conn,P Jeffrey AU - Markou,Athina AU - Cosford,Nicholas D P TI - Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence SN - 1520-4804 PY - 2013///0205 KW - Administration, Oral KW - Allosteric Regulation KW - Animals KW - Behavior, Animal KW - drug effects KW - Brain KW - Glutamic Acid KW - metabolism KW - HEK293 Cells KW - Humans KW - Indoles KW - chemistry KW - Microsomes, Liver KW - Molecular Structure KW - Nicotine KW - administration & dosage KW - Rats KW - Receptors, Metabotropic Glutamate KW - agonists KW - Structure-Activity Relationship KW - Tissue Distribution KW - Tobacco Use Disorder KW - drug therapy N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural UR - https://doi.org/10.1021/jm3005306 ER -