TY - GEN AU - Su,Xinming AU - Floyd,Desiree H AU - Hughes,Alun AU - Xiang,Jingyu AU - Schneider,Jochen G AU - Uluckan,Ozge AU - Heller,Emanuela AU - Deng,Hongju AU - Zou,Wei AU - Craft,Clarissa S AU - Wu,Kaiming AU - Hirbe,Angela C AU - Grabowska,Dorota AU - Eagleton,Mark C AU - Townsley,Sarah AU - Collins,Lynne AU - Piwnica-Worms,David AU - Steinberg,Thomas H AU - Novack,Deborah V AU - Conley,Pamela B AU - Hurchla,Michelle A AU - Rogers,Michael AU - Weilbaecher,Katherine N TI - The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling SN - 1558-8238 PY - 2013///0201 KW - Adenosine Diphosphate KW - physiology KW - Animals KW - Arthritis, Experimental KW - complications KW - Bone Neoplasms KW - Bone Remodeling KW - drug effects KW - Bone Resorption KW - physiopathology KW - Carcinoma KW - Cell Adhesion KW - Cells, Cultured KW - Clopidogrel KW - Enzyme Activation KW - Female KW - Mammary Neoplasms, Experimental KW - pathology KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Osteoclasts KW - Osteoporosis KW - etiology KW - Ovariectomy KW - Phosphatidylinositol 3-Kinases KW - Phosphoinositide-3 Kinase Inhibitors KW - Platelet Glycoprotein GPIIb-IIIa Complex KW - Purinergic P2Y Receptor Antagonists KW - pharmacology KW - Receptors, Purinergic P2Y12 KW - deficiency KW - Specific Pathogen-Free Organisms KW - Ticlopidine KW - analogs & derivatives KW - rap1 GTP-Binding Proteins N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S UR - https://doi.org/10.1172/JCI38576 ER -