Saucerneol D inhibits eicosanoid generation and degranulation through suppression of Syk kinase in mast cells. [electronic resource]
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Dec 2012
- 4382-8 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1873-6351
10.1016/j.fct.2012.08.053 doi
Animals Arachidonate 5-Lipoxygenase--genetics Bone Marrow Cells--cytology Cell Degranulation--drug effects Cyclooxygenase 2--genetics Eicosanoids--antagonists & inhibitors Intracellular Signaling Peptides and Proteins--genetics Leukotriene C4--genetics Lignans--pharmacology MAP Kinase Signaling System Male Mast Cells--drug effects Mice Mice, Inbred BALB C Mitogen-Activated Protein Kinase 3--metabolism Mitogen-Activated Protein Kinases--metabolism NF-kappa B--metabolism Phospholipase C gamma--genetics Phosphorylation Plant Extracts--pharmacology Protein-Tyrosine Kinases--genetics Saururaceae--chemistry Syk Kinase