Iglesias-Bartolome, Ramiro
mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. [electronic resource]
- Cell stem cell Sep 2012
- 401-14 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
1875-9777
10.1016/j.stem.2012.06.007 doi
Animals
Carcinoma, Squamous Cell--enzymology
Cell Compartmentation--drug effects
Cell Death--drug effects
Cell Proliferation--drug effects
Cells, Cultured
Cellular Senescence--drug effects
Clone Cells
Cytoprotection--drug effects
Epithelial Cells--drug effects
Head and Neck Neoplasms--enzymology
Humans
Keratinocytes--drug effects
Mice
Mouth Mucosa--drug effects
Mucositis--enzymology
Oxidative Stress--drug effects
Radiation Injuries--enzymology
Radiation, Ionizing
Sirolimus--pharmacology
Stem Cells--drug effects
Superoxide Dismutase--metabolism
TOR Serine-Threonine Kinases--antagonists & inhibitors