TY  - GEN
AU  - Eckford,Paul D W
AU  - Li,Canhui
AU  - Ramjeesingh,Mohabir
AU  - Bear,Christine E
TI  - Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner
SN  - 1083-351X
PY  - 2013///0107
KW  - Adenosine Triphosphate
KW  - chemistry
KW  - Aminophenols
KW  - Animals
KW  - Caprylates
KW  - Cell Line
KW  - Chromatography, Affinity
KW  - Cystic Fibrosis Transmembrane Conductance Regulator
KW  - Detergents
KW  - Fluorocarbons
KW  - Humans
KW  - Ion Channel Gating
KW  - drug effects
KW  - Liposomes
KW  - Mutant Proteins
KW  - Mutation, Missense
KW  - Phosphorylation
KW  - Protein Binding
KW  - Protein Conformation
KW  - Protein Processing, Post-Translational
KW  - Quinolones
KW  - Sequence Deletion
KW  - Signal Transduction
KW  - Spodoptera
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1074/jbc.M112.393637
ER  -