Eckford, Paul D W <br/><br/>
Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.  [electronic resource] 

 -  The Journal of biological chemistry  Oct 2012 
 - 36639-49 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1083-351X 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M112.393637  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adenosine Triphosphate--chemistry<br/>Aminophenols--chemistry<br/>Animals<br/>Caprylates--chemistry<br/>Cell Line<br/>Chromatography, Affinity<br/>Cystic Fibrosis Transmembrane Conductance Regulator--chemistry<br/>Detergents--chemistry<br/>Fluorocarbons--chemistry<br/>Humans<br/>Ion Channel Gating--drug effects<br/>Liposomes<br/>Mutant Proteins--chemistry<br/>Mutation, Missense<br/>Phosphorylation<br/>Protein Binding<br/>Protein Conformation--drug effects<br/>Protein Processing, Post-Translational<br/>Quinolones--chemistry<br/>Sequence Deletion<br/>Signal Transduction--drug effects<br/>Spodoptera