TY  - GEN
AU  - Muller,Patrick Y
AU  - Milton,Mark N
TI  - The determination and interpretation of the therapeutic index in drug development
SN  - 1474-1784
PY  - 2012///1211
KW  - Animals
KW  - Biomarkers, Pharmacological
KW  - metabolism
KW  - Drug Discovery
KW  - trends
KW  - Drug-Related Side Effects and Adverse Reactions
KW  - Humans
KW  - Pharmaceutical Preparations
KW  - administration & dosage
KW  - Treatment Outcome
N1  - Publication Type: Journal Article; Review
UR  - https://doi.org/10.1038/nrd3801
ER  -