RGS2 overexpression or G(i) inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cells. [electronic resource]
- Journal of molecular and cellular cardiology Nov 2012
- 687-94 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Intramural
1095-8584
10.1016/j.yjmcc.2012.08.007 doi
Action Potentials Adenoviridae--genetics Adrenergic beta-Agonists--pharmacology Animals Calcium-Binding Proteins--metabolism Cell Shape Cells, Cultured Cyclic AMP Cyclic AMP-Dependent Protein Kinases--antagonists & inhibitors GTP-Binding Protein alpha Subunits, Gi-Go--metabolism Genetic Vectors Isoproterenol--pharmacology Pertussis Toxin--pharmacology Phosphorylation Protein Kinase Inhibitors--pharmacology Protein Processing, Post-Translational RGS Proteins--genetics Rabbits Recombinant Proteins--genetics Ryanodine Receptor Calcium Release Channel--metabolism Second Messenger Systems Sinoatrial Node--cytology Transfection