TY - GEN AU - Shah,Manish B AU - Wilderman,P Ross AU - Pascual,Jaime AU - Zhang,Qinghai AU - Stout,C David AU - Halpert,James R TI - Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules SN - 1520-4995 PY - 2012///1119 KW - Amlodipine KW - chemistry KW - Animals KW - Aryl Hydrocarbon Hydroxylases KW - Calcium Channel Blockers KW - Crystallography, X-Ray KW - Cytochrome P-450 CYP2B6 KW - Cytochrome P450 Family 2 KW - Humans KW - Oxidoreductases, N-Demethylating KW - Protein Binding KW - drug effects KW - Protein Structure, Secondary KW - Protein Structure, Tertiary KW - Rabbits KW - Substrate Specificity N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural UR - https://doi.org/10.1021/bi300894z ER -