TY  - GEN
AU  - Fan,Xuejun
AU  - Brezski,Randall J
AU  - Fa,Ming
AU  - Deng,Hui
AU  - Oberholtzer,Allison
AU  - Gonzalez,Anneliese
AU  - Dubinsky,William P
AU  - Strohl,William R
AU  - Jordan,Robert E
AU  - Zhang,Ningyan
AU  - An,Zhiqiang
TI  - A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy
SN  - 1465-542X
PY  - 2015///0624
KW  - Amino Acid Sequence
KW  - Animals
KW  - Antibodies, Monoclonal, Humanized
KW  - chemistry
KW  - Antibody-Dependent Cell Cytotoxicity
KW  - immunology
KW  - Cell Line
KW  - Disease Models, Animal
KW  - Female
KW  - Humans
KW  - Matrix Metalloproteinases
KW  - metabolism
KW  - Mice
KW  - Molecular Sequence Data
KW  - Neoplasms
KW  - drug therapy
KW  - Protein Binding
KW  - Proteolysis
KW  - Receptor, ErbB-2
KW  - antagonists & inhibitors
KW  - Receptors, IgG
KW  - Trastuzumab
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1186/bcr3240
ER  -