Fan, Xuejun <br/><br/>
A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy.  [electronic resource] 

 -  Breast cancer research : BCR  Aug 2012 
 - R116 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1465-542X 
<br/><br/><label>Standard No.: </label>10.1186/bcr3240  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amino Acid Sequence<br/>Animals<br/>Antibodies, Monoclonal, Humanized--chemistry<br/>Antibody-Dependent Cell Cytotoxicity--immunology<br/>Cell Line<br/>Disease Models, Animal<br/>Female<br/>Humans<br/>Matrix Metalloproteinases--metabolism<br/>Mice<br/>Molecular Sequence Data<br/>Neoplasms--drug therapy<br/>Protein Binding<br/>Proteolysis<br/>Receptor, ErbB-2--antagonists & inhibitors<br/>Receptors, IgG--metabolism<br/>Trastuzumab<br/>Xenograft Model Antitumor Assays