Induction of P-glycoprotein and Bcrp at the rat blood-brain barrier following a subchronic morphine treatment is mediated through NMDA/COX-2 activation. [electronic resource]
- Journal of neurochemistry Nov 2012
- 491-503 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1471-4159
10.1111/j.1471-4159.2012.07890.x doi
ATP Binding Cassette Transporter, Subfamily B--genetics ATP Binding Cassette Transporter, Subfamily B, Member 1--genetics ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP-Binding Cassette Transporters--genetics Analysis of Variance Animals Blood Vessels--drug effects Blood-Brain Barrier--drug effects Brain--anatomy & histology Cell Line, Transformed Cyclooxygenase 2--metabolism Cyclooxygenase Inhibitors--pharmacology Dizocilpine Maleate--pharmacology Dose-Response Relationship, Drug Excitatory Amino Acid Antagonists--pharmacology Gene Expression Regulation--drug effects Glutamic Acid--metabolism Humans Iloprost--pharmacology Male Meloxicam Misoprostol--pharmacology Morphine--administration & dosage N-Methylaspartate--metabolism Narcotics--administration & dosage RNA, Messenger--metabolism Rats Rats, Sprague-Dawley Thiazines--pharmacology Thiazoles--pharmacology Time Factors