Identification of DNA repair pathways that affect the survival of ovarian cancer cells treated with a poly(ADP-ribose) polymerase inhibitor in a novel drug combination. [electronic resource]
- Molecular pharmacology Oct 2012
- 767-76 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1521-0111
10.1124/mol.112.080614 doi
Antineoplastic Agents--pharmacology Ataxia Telangiectasia Mutated Proteins Benzimidazoles--pharmacology Cell Cycle Checkpoints Cell Cycle Proteins--metabolism Cell Line, Tumor Cell Survival--drug effects Checkpoint Kinase 1 Checkpoint Kinase 2 DNA Damage DNA Repair Drug Synergism Enzyme Activation Female Floxuridine--pharmacology Homologous Recombination Humans Ovarian Neoplasms--pathology PTEN Phosphohydrolase--genetics Poly(ADP-ribose) Polymerase Inhibitors Protein Kinases--metabolism Protein Serine-Threonine Kinases--metabolism Signal Transduction