TY - GEN AU - Trinh,Mimi A AU - Kaphzan,Hanoch AU - Wek,Ronald C AU - Pierre,Philippe AU - Cavener,Douglas R AU - Klann,Eric TI - Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility SN - 2211-1247 PY - 2013///0226 KW - Activating Transcription Factor 4 KW - metabolism KW - Animals KW - Behavior, Animal KW - drug effects KW - Benzamides KW - administration & dosage KW - Brain KW - Cognition KW - Eukaryotic Initiation Factor-2 KW - Exploratory Behavior KW - Gene Deletion KW - Grooming KW - Humans KW - Mice KW - Mice, Knockout KW - Motor Activity KW - Organ Specificity KW - Phosphorylation KW - Piperidines KW - Prefrontal Cortex KW - Protein Biosynthesis KW - Protein Serine-Threonine Kinases KW - deficiency KW - Receptors, N-Methyl-D-Aspartate KW - Reflex, Startle KW - Reversal Learning KW - Rotarod Performance Test KW - Schizophrenia KW - enzymology KW - eIF-2 Kinase N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1016/j.celrep.2012.04.010 ER -