TY  - GEN
AU  - Ho,Alan L
AU  - Musi,Elgilda
AU  - Ambrosini,Grazia
AU  - Nair,Jayasree S
AU  - Deraje Vasudeva,Shyamprasad
AU  - de Stanchina,Elisa
AU  - Schwartz,Gary K
TI  - Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype
SN  - 1932-6203
PY  - 2013///0319
KW  - Adaptor Proteins, Signal Transducing
KW  - metabolism
KW  - Animals
KW  - Apoptosis
KW  - drug effects
KW  - Benzimidazoles
KW  - pharmacology
KW  - Cell Cycle Proteins
KW  - Cell Line, Tumor
KW  - Cell Survival
KW  - Drug Resistance, Neoplasm
KW  - Drug Synergism
KW  - GTP-Binding Protein alpha Subunits
KW  - genetics
KW  - GTP-Binding Protein alpha Subunits, Gq-G11
KW  - Genotype
KW  - Humans
KW  - Mechanistic Target of Rapamycin Complex 2
KW  - Melanoma
KW  - drug therapy
KW  - Mice
KW  - Mitogen-Activated Protein Kinase Kinases
KW  - antagonists & inhibitors
KW  - Models, Biological
KW  - Morpholines
KW  - Multiprotein Complexes
KW  - Mutation
KW  - Myeloid Cell Leukemia Sequence 1 Protein
KW  - Phosphoproteins
KW  - Phosphorylation
KW  - Protein Kinase Inhibitors
KW  - Proto-Oncogene Proteins B-raf
KW  - Proto-Oncogene Proteins c-akt
KW  - Proto-Oncogene Proteins c-bcl-2
KW  - Receptor, IGF Type 1
KW  - TOR Serine-Threonine Kinases
KW  - Uveal Neoplasms
KW  - Xenograft Model Antitumor Assays
KW  - Uveal Melanoma
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1371/journal.pone.0040439
ER  -