Functional differences exist between TNFα promoters encoding the common -237G SNP and the rarer HLA-B*5701-linked A variant. [electronic resource]
- PloS one 2012
- e40100 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0040100 doi
Animals B-Lymphocytes--drug effects Base Sequence Cell Line DNA Methylation--drug effects Epigenesis, Genetic--drug effects Genes, Reporter HIV Infections--genetics HLA-B Antigens--genetics Haplotypes--genetics Homozygote Humans Lipopolysaccharides--pharmacology Luciferases--metabolism Lymphocyte Activation--drug effects Mice Molecular Sequence Data Monocytes--cytology Polymorphism, Single Nucleotide--genetics Promoter Regions, Genetic--genetics Protein Binding--drug effects RNA, Messenger--genetics Software Solubility Tetradecanoylphorbol Acetate--pharmacology Transcription Factors--metabolism Tumor Necrosis Factor-alpha--biosynthesis