TY  - GEN
AU  - Huber,John D
AU  - Bentzien,Jörg
AU  - Boyer,Stephen J
AU  - Burke,Jennifer
AU  - De Lombaert,Stéphane
AU  - Eickmeier,Christian
AU  - Guo,Xin
AU  - Haist,James V
AU  - Hickey,Eugene R
AU  - Kaplita,Paul
AU  - Karmazyn,Morris
AU  - Kemper,Raymond
AU  - Kennedy,Charles A
AU  - Kirrane,Thomas
AU  - Madwed,Jeffrey B
AU  - Mainolfi,Elizabeth
AU  - Nagaraja,Nelamangara
AU  - Soleymanzadeh,Fariba
AU  - Swinamer,Alan
AU  - Eldrup,Anne B
TI  - Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat
SN  - 1520-4804
PY  - 2012///1126
KW  - Animals
KW  - Benzamides
KW  - chemical synthesis
KW  - Biological Availability
KW  - Blood Platelets
KW  - cytology
KW  - Cell Line
KW  - Cell Membrane Permeability
KW  - Cell Size
KW  - Cytochrome P-450 Enzyme Inhibitors
KW  - Dogs
KW  - ERG1 Potassium Channel
KW  - Ether-A-Go-Go Potassium Channels
KW  - antagonists & inhibitors
KW  - Guanidines
KW  - Humans
KW  - Male
KW  - Membranes, Artificial
KW  - Microsomes, Liver
KW  - metabolism
KW  - Models, Molecular
KW  - Myocardial Infarction
KW  - drug therapy
KW  - Myocardial Reperfusion Injury
KW  - prevention & control
KW  - Permeability
KW  - Protein Isoforms
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Sodium-Hydrogen Exchanger 1
KW  - Sodium-Hydrogen Exchangers
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm300601d
ER  -