Huber, John D <br/><br/>
Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat.  [electronic resource] 

 -  Journal of medicinal chemistry  Aug 2012 
 - 7114-40 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm300601d  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Benzamides--chemical synthesis<br/>Biological Availability<br/>Blood Platelets--cytology<br/>Cell Line<br/>Cell Membrane Permeability<br/>Cell Size<br/>Cytochrome P-450 Enzyme Inhibitors<br/>Dogs<br/>ERG1 Potassium Channel<br/>Ether-A-Go-Go Potassium Channels--antagonists & inhibitors<br/>Guanidines--chemical synthesis<br/>Humans<br/>Male<br/>Membranes, Artificial<br/>Microsomes, Liver--metabolism<br/>Models, Molecular<br/>Myocardial Infarction--drug therapy<br/>Myocardial Reperfusion Injury--prevention & control<br/>Permeability<br/>Protein Isoforms--antagonists & inhibitors<br/>Rats<br/>Rats, Sprague-Dawley<br/>Sodium-Hydrogen Exchanger 1<br/>Sodium-Hydrogen Exchangers--antagonists & inhibitors<br/>Structure-Activity Relationship