TY - GEN AU - Kass,David A TI - Cardiac role of cyclic-GMP hydrolyzing phosphodiesterase type 5: from experimental models to clinical trials SN - 1546-9549 PY - 2012///1227 KW - Carbolines KW - therapeutic use KW - Cardiomyopathy, Dilated KW - drug therapy KW - Cyclic AMP KW - metabolism KW - Cyclic GMP KW - Cyclic GMP-Dependent Protein Kinases KW - drug effects KW - Cyclic Nucleotide Phosphodiesterases, Type 5 KW - Fibrosis KW - Heart KW - Heart Failure KW - Humans KW - Hypertrophy KW - Myocardium KW - Phosphodiesterase 5 Inhibitors KW - Phosphoric Diester Hydrolases KW - Piperazines KW - Purines KW - Sildenafil Citrate KW - Sulfones KW - TRPC Cation Channels KW - Tadalafil KW - Transforming Growth Factor beta KW - Ventricular Remodeling KW - physiology N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Review UR - https://doi.org/10.1007/s11897-012-0101-0 ER -