TY  - GEN
AU  - Collin,Nicolas
AU  - Assumpção,Teresa C F
AU  - Mizurini,Daniella M
AU  - Gilmore,Dana C
AU  - Dutra-Oliveira,Angélica
AU  - Kotsyfakis,Michalis
AU  - Sá-Nunes,Anderson
AU  - Teixeira,Clarissa
AU  - Ribeiro,José M C
AU  - Monteiro,Robson Q
AU  - Valenzuela,Jesus G
AU  - Francischetti,Ivo M B
TI  - Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly Lutzomyia longipalpis blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo
SN  - 1524-4636
PY  - 2012///1029
KW  - Amino Acid Sequence
KW  - Animals
KW  - Anti-Inflammatory Agents
KW  - chemistry
KW  - Blood Coagulation
KW  - drug effects
KW  - Calorimetry
KW  - Cell Line, Tumor
KW  - Chlorides
KW  - Cloning, Molecular
KW  - Disease Models, Animal
KW  - Dose-Response Relationship, Drug
KW  - Factor Xa
KW  - metabolism
KW  - Factor Xa Inhibitors
KW  - Female
KW  - Ferric Compounds
KW  - Fibrinolytic Agents
KW  - HEK293 Cells
KW  - Humans
KW  - Inflammation
KW  - blood
KW  - Insect Proteins
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Molecular Sequence Data
KW  - Molecular Weight
KW  - Partial Thromboplastin Time
KW  - Protein Binding
KW  - Prothrombin Time
KW  - Psychodidae
KW  - Rats
KW  - Receptor, PAR-2
KW  - antagonists & inhibitors
KW  - Recombinant Proteins
KW  - Salivary Glands
KW  - Surface Plasmon Resonance
KW  - Thromboplastin
KW  - Thrombosis
KW  - Time Factors
N1  - Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1161/ATVBAHA.112.253906
ER  -