TY  - GEN
AU  - Parekh,Jignesh M
AU  - Shah,Dhaval K
AU  - Sanyal,Mallika
AU  - Yadav,Manish
AU  - Shrivastav,Pranav S
TI  - Development of an SPE-LC-MS/MS method for simultaneous quantification of bosentan and its active metabolite hydroxybosentan in human plasma to support a bioequivalence study
SN  - 1873-264X
PY  - 2013///0207
KW  - Administration, Oral
KW  - Adult
KW  - Antihypertensive Agents
KW  - administration & dosage
KW  - Area Under Curve
KW  - Biotransformation
KW  - Bosentan
KW  - Calibration
KW  - Chromatography, High Pressure Liquid
KW  - standards
KW  - Chromatography, Reverse-Phase
KW  - Cross-Over Studies
KW  - Fasting
KW  - blood
KW  - Half-Life
KW  - Humans
KW  - Hydroxylation
KW  - India
KW  - Male
KW  - Metabolic Clearance Rate
KW  - Reference Standards
KW  - Reproducibility of Results
KW  - Sensitivity and Specificity
KW  - Solid Phase Extraction
KW  - Sulfonamides
KW  - Tablets
KW  - Tandem Mass Spectrometry
KW  - Therapeutic Equivalency
KW  - Young Adult
N1  - Publication Type: Journal Article; Randomized Controlled Trial
UR  - https://doi.org/10.1016/j.jpba.2012.06.027
ER  -